Wistar researchers invigorate 'exhausted' immune cells

The War Resisters chronic infection, the body's immune cells often tired and major effect. To restore the vitality of the research institute wistar how he found the killer cells to block a key receptor on the surface of t survey the development of new treatments for diseases such as AIDS in advance, and c amhapnida and hepatitis.

The study, September 15 days to publish the proceedings online at the National Academy of Sciences (pnas), wistar Research Institute and colleagues using antibodies to block the investigation report to the receptor, known as the death of programming - 1 (police - 1), Chronically infected person's immune jwihapnida dramatically restored. In addition, they found a way to distinguish t cells that sueopneun hands and vitality.

Police are helping researchers to develop research results - 1 blocking agents, and how to select patients who provide the greatest benefits to suit the novel as it obtained the drugs, the study's lead author, e. John wherry, doctorate, assistant professor of Immunology wistar of the program.
"Blocking the Department - which provides a novel tool to combat on May 1 using a chronic infection, as well as some cancers, like heuksaekjong, it takes the immune system to destroy the" wherry said. Infection often results in examples of t - cell depletion of AIDS, hepatitis and hepatitis c, he says.

Police are continuing to study wherry - 1 to provide the foundation for the development of therapeutic antibodies, and in order to suppress the receptors. Pharmaceutical companies know wherry preparing to test c. One patient has hepatitis agent

Researchers have known that cells t - to induce death in cancer cells or white blood cells infected with hands - fewer features gradually over time. Previous research, and his colleagues found wherry chronic infection in this process, dramatic changes in gene expression that killer cells are immune cells to respond to t-consuming and slowed down the pathogen. Next game one of the investigators to determine gene wistar a central role in the immune reaction, the boundaries of a drill - the police - 1, the police - 1 receptor proteins that produce these cells bearing the face of t suit.

Depending on - to experiment, the police discovered - 1 receptors to block when one of the cell culture used to make antibodies to the protein-binding nature of their ligands t - to alleviate the blood cells. The police protest - one that acts as a "brake" t - cell functions.

This reaction is designed to protect suspects wherry against the ravages of the body over - chronic suit today to stimulate the immune system. "Cause damage to the immune system will suit a lot of effort for the 2006 infection control the infection suit is not clear if the graves themselves and try to sell it to suit it better than dying from infections and immune to live - brokerage incidental damage, "He said.

Current Research, and colleagues wherry lymphocytic choriomeningitis virus from connecting to the effects of experimental mice infected with the police - 1 antibodies to the receptor, thus releasing the "brake" to the immune system. And they're two different subsets of cells to study killer t: with them, leading police - 1 receptors and the people's representation through the "intermediate" representation. The leading theory that the Department to study cells - one t representation, to symbolize the deep fatigue, the antibody to the police - one of the largest benefits.

Their raid, to discover what it is. They injected cells infected with two different jwiyi mouse, and then gave a subset of the Department - 1 antibodies. Intermediate t cells that express the vitality injected mice recovered - 1:00, the police - the highest representation of the mouse while it does not. "t, you may express more of a killer cells - has already promised to the police cell death," wherry said.

t know the drug is a subset of the antibody response of cells to help doctors identify patients who respond to these novel agents to reach a broad range of clinical trials, wherry says. "We promise to optimize the same suit. Tools and medical treatment to minimize waste," he said.

The study provides insight into how potential Says wherry around - 1. Sophistication suit to prevent his own agents to stimulate the immune response, the body's own organization, errantly attacks. The same manner, some people suggested strategies for disarming self-immune diseases such as Lupus, he says. "If our police - to understand how to set up a separate one widget to strengthen tolerance, which is a source of insight into how to turn on the immune system to treat disease," wherry said.

Source : The Wistar Institute